Telomere length is associated with disease severity and declines with age in dyskeratosis congenita
Background Dyskeratosis congenita is a cancer-prone bone marrow failure syndrome caused by aberrations in telomere biology.Design and Methods We studied 65 patients with dyskeratosis congenita and 127 unaffected relatives.Telomere length was measured by automated multicolor flow fluorescence in situ hybridization in peripheral blood leukocyte subse